Objective: To observe the influence of compound phenytoin sodium gel (CPSG) for experimental animals on restoration of the wound's surface and bacterial infection. Method: The incised wound model of mice was established

CPSG (4.25

4.55 g·kg-1)was external applied for 12 days and the wound contraction rate were observed after treatment for 3

6

8

10

12 days. Rats incised wound model accompanied by staphylococcus aureus were replicated

CPSG (1.70

1.82 g·kg-1)was external applied for 12 d

and the wound recovery rate were detected after treatment for 3

6

8

10

12 days. The histopathological changes of wound healing tissue were examined. Result: Compared with the wound contraction rate of gel group (16.77±4.79)%

(29.95±5.63)%

(50.69±4.19)%

(67.47±5.13)%

(82.48±4.40)%

those in low and high doses of CPSG were (20.16±5.78)%

(40.02±9.79)%

(71.04±7.27)%

(96.14±2.53)%

(99.44±1.30)%;(28.50±4.77)%

(55.66±8.39)%

(79.67±5.11)%

(96.14±2.53)%

(100.00±0.00)% respectively(P<0.05

P<0.01

P<0.01

P<0.01. P<0.01

P<0.01

P<0.01

P<0.01

P<0.01)after treatment for 3

6

8

10

12 days in mice. The wound recovery rate of the low and high dose of CPSG were (29.45±5.11)%

(50.17±4.92)%

(72.48±5.05)%

(87.44±4.11)%

(96.66±3.75)%;(33.71±3.43)%

(58.67±5.59)%

(81.86±4.15)%

(95.92±2.39)%

(100.00±0.00)% higher than (20.71±3.58)%

(40.42±3.89)%

(58.53±6.21)%

(74.71±9.23)%

(86.47±7.15)% of gel group(all P<0.01)in the treatment of 3

6

8

10

12 days. Conclusion: CPSG could promote the restoration of the wound's surface in the animals with experimental trauma and bacterial infection.