Objective: To study the effect of intestinal mucosa permeability

endotoxin blood and ammonia of Severe hepatitis treated with multi-ways administration of Chinese medicine. Method: Eighty-eight severe hepatitis patients were randomLy distributed into therapy group (57 cases)and control group(31 cases). According to clinic sequence

the control group was treated with conventional therapy methods such as protecting liver

supporting treatment and artificial liver support system

in the same time the therapy group was treated with conventional therapy plus multi-ways administration of Chinese medicine such as retention enema

sticking

oral administration dialectically and intravenous drip with traditional Chinese medicine. Result: The total effective rate was 82.46% in the therapy group

in which 16 cases were obviously improved

18 cases were improved

7 cases were ineffective and 1 case was sheded; whereas the total effective rate was 61.29% in the control group

in which 3 were cases cured

7 cases were obviously improved

9 cases were improved

12 cases were ineffective

and 2 cases were sheded. The difference between the two groups was obvious (P<0.05)

with the treatment group being better than the control group.A obvious difference(P<0.05) was exhibited in refractory complications

time of hospitalization

number of times of artificial liver treatment

with the treatment group being better than the control group. Conclusion: Multi-ways administration of Chinese medicine could promote the recovery of severe hepatitis patients

reduce the refractory complications

cost

time of hospitalization and the number of times of artificial liver treatment of severe hepatitis patients

thus is a valuable optimization treatment method.