Objective: To optimize preparation technology of total lignans from Schisandrae Sphenantherae Fructus softcapsules. Method: The content of total lignans was determined by UV spectrophotometry.With corn oil and polyethylene glycol 600(PEG600) as dispersant

hydrogenated vegetable oil and sodium carboxymethyl cellulose(CMC-Na) as stabilizer

polysorbate80(Tween80) as co-solvent

optimum prescription of capsules content was screened.With capsules yield and rolling phenomenon as comprehensive evaluation index

orthogonal test was adopted to investigate effects of inlet temperature

outlet temperature and rotating basket drying time on preparation technology. Result: The best prescription of capsules content was main medicine-corn oil-PEG600-1

2-propanediol-CMC-Na-hydrogenated vegetable oil-Tween80-water(44: 10: 15: 1: 8: 9: 3: 10).Optimum preparation process was as following:dried by basket method at room temperature for 24 h with inlet temperature of 50℃ and outlet temperature at 20℃. Conclusion: This optimized process was feasible

stable and reasonable.