星点设计-效应面法优化沙棘黄酮提取物分散片处方

申雪丽; 袁勇; 黄川生; 王新春; 尹俊涛

doi:10.11653/syfj2013170019

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星点设计-效应面法优化沙棘黄酮提取物分散片处方

更新时间：2024-01-04

- 星点设计-效应面法优化沙棘黄酮提取物分散片处方
- Optimization of Formulation of Seabuckthorn Flavonoids Extract Dispersible Tablets by Central Composite Design/Response Surface Methodology
- 中国实验方剂学杂志 2013年19卷第17期页码：19-22
- 作者机构：
- 作者简介：
- 基金信息：
  
  新疆兵团火炬计划项目(2011BD021)
- DOI：10.11653/syfj2013170019
  中图分类号：
- 纸质出版日期：2013
- 稿件说明：
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申雪丽, 袁勇, 黄川生, 等. 星点设计-效应面法优化沙棘黄酮提取物分散片处方[J]. 中国实验方剂学杂志, 2013,19(17):19-22.

SHEN Xue-li, YUAN Yong, HUANG Chuan-sheng, et al. Optimization of Formulation of Seabuckthorn Flavonoids Extract Dispersible Tablets by Central Composite Design/Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(17): 19-22.
申雪丽, 袁勇, 黄川生, 等. 星点设计-效应面法优化沙棘黄酮提取物分散片处方[J]. 中国实验方剂学杂志, 2013,19(17):19-22. DOI： 10.11653/syfj2013170019.

SHEN Xue-li, YUAN Yong, HUANG Chuan-sheng, et al. Optimization of Formulation of Seabuckthorn Flavonoids Extract Dispersible Tablets by Central Composite Design/Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(17): 19-22. DOI： 10.11653/syfj2013170019.

摘要

目的: 优化沙棘黄酮提取物分散片的处方。方法: 以崩解时间、混悬系数和抗张强度为指标

交联聚维酮(PVPP)、羟丙基纤维素(HPC)、聚维酮(PVP-K30)用量为自变量

采用星点设计试验优化处方

数据进行多元线性和二项式非线性方程拟合

通过效应面法确定最佳处方。结果: 最佳成型工艺为PVPP 50.0 mg/片

HPC 9.2 mg/片

PVP-K30 7.0 mg/片。预测值和测定值非常接近

偏差0.32%。结论: 星点设计-效应面法可用于优选沙棘黄酮提取物分散片的处方工艺

优选的成型工艺稳定可行。

Abstract

Objective: To optimize formulation of seabuckthorn flavonoids extract dispersible tablets by central composite design-response surface methodology. Method: With disintegration time

suspension coefficient and tensile strength as dependent variables

the amounts of PVPP

HPC and PVP-K30 as independent variables

formulation was optimized by central composite design

data was fitted by multiple linear and binomial nonlinear equations

response surface methodology was adopted to determine optimum formulation. Result: Optimal formulation was proposed to contain PVPP 50.0 mg/table

HPC 9.2 mg/table and PVP-K30 7.0 mg/table.Dissolution test of optimal formulation indicated that there was low deviation (0.32%) between the predicted value and the measured value. Conclusion: Central composite design-response surface methodology was convenient to optimize molding technology of seabuckthorn flavonoids extract dispersible tablets

optimized molding technology was stable and feasible.

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