Objective: To optimize water extraction and alcohol precipitation technology of Jianwei Qingchang mixtures. Method: With composite score of the total content of rhein

emodin and rhubarb phenol

dry extract yield as index

effects of the amount of water

extraction times and time on extraction technology was investigated by orthogonal test;With the total content of rhein

emodin and rhubarb phenol as index

orthogonal test was adopted to investigate effects of the concentration of alcohol precipitation and relative density of concentrate on alcohol precipitation technology. Result: Optimum water extraction and alcohol precipitation technology was as following:extracted 2 times with 10 folds the amount of water

3 h each time

extracts were combined and concentrated to a relative density of 1.05 g·mL-1

added 95% ethanol to precipitate the volume fraction of ethanol with 60%. Conclusion: Optimized water extraction and alcohol precipitation technology was stable and feasible

it could provide a reference for standardized production of Jianwei Qingchang mixtures.