Objective: To investigate the influence of active compounds of Angelicae Dahuricae Radix(coumarin/volatile oil) on the intestinal absorption of puerarin

baicalin

ferelic

liquiritin and glycyrrhizic acid

respectively. To explore the influence law of Angelicae Dahricae Radix on the intestinal absorption of the active compounds of herb-pairs. Method: Everted gut sac was used to study compatible effects of Angelicae Dahuricae Radix and herb-pairs(Puerariae Lobatae Radix

Scutellariae Radix

Chuanxiong Rhizoma

Glycyrrhizae Radix et Rhizoma) on intestinal absorption of puerarin

baicalin

ferelic acid

liquiritin and glycyrrhizic acid. Result: Results showed that Angelicae Dahuricae Radix could enhance the absorption of puerarin(1.7 times ) and baicalin (4.74 times )

and has no effect on the intestinal absorption of ferulic acid

but could significantly restrain the intestinal absorption of liquiritin and glycyrrhizic acid. Conclusion: These results confirmed that synergistic therapeutic effect of compatibility of Angelicae Dahuricae Radix and Puerariae Lobatae Radix

Angelicae Dahuricae Radix and Scutellariae Radix not only lay in the different active ingredients acting on the different target

but also shown as active compounds of Radix Angelicae dahuricae could increasing the intestinal absorption of puerarin and baicalin. The mechanism of Angelicae Dahuricae Radix and Chuangxiong Rhizoma

Angelicae Dahuricae Radix and Glycyrrhizae Radix et Rhizoma may be not related to the influence of Angelicae Dahuricae Radix on the intestinal absorption of ferulic acid

liguiritin and glycyrrhizic acid.