Objective: To observe the effect of Buxin decoction on the content of B-type natriuretic peptide(BNP)

troponin I(TNI)

adenosine triphosphate(ATP) in rats with heart failure after myocardial infarction. Method: Sixty rats were randomly divided into 6 groups:model group

sham-operation group

trimetazidine(TMZ) group low

middle and high dosage groups of Buxin decoction

10 rats in each group. The acute myocardial infarction (AMI) model was induced by ligation of the left anterior descending artery

oral administration lasted for 8 weeks.The BNP

TNI level was determined by enzyme-linked immuno sorbent assay(ELISA)

and the contents of adenosine monophosphate(AMP)

adenosine diphosphate(ADP) and ATP were measured by HPLC. Result: Before treatment

compared with the sham-operation group

BNP and TNI level in model and treated group significantly increased (P<0.01). After treatment

compared with model group

BNP and TNI level in Buxin decoction groups significantly decreased (P<0.01). Compared with the sham-operation group

the ATP content in model group was significantly lower (P<0.01). After the intervention of Buxin decoction

the ATP content increased in the high-dose and low dose group(P<0.05

P<0.01). Conclusion: Buxin decoction can reduce the content of BNP and TNI in rats with heart failure after myocardial infarction

and improve energy metabolism.