Objective: To investigate effect of Xiaoyao San on related indexes of the prefrontal cortex in rats model of Alzheimer's disease. Method: The male SD rats were randomly divided into 4 groups

model group (group B)

western medicine group (C group)

Chinese medicine group (D group) respectively by intraperitoneal injection of D-galactose and A-β1-42 peptide bilateral hippocampal injection molding (D-galactose 10 mL (100 mg·kg-1)

once a day

continuous injection for 42 d;A-β 2 μL (10 μg) once

normal group (group A) was given normal saline. After modeling

C and D groups were given oxiracetam solution and Xiaoyao San ig once for 28 days. Result: In C and D groups

compared with B group

the number of attempts and the correct behavior rate is obvious

the difference was statistically significant (P<0.05 and P<0.01);In B group

compared with A group

number of attempts and the correct behavior rate is poor

the difference was statistically significant (P<0.05 and P<0.01);there was no significant difference in C

and D groups compared with A groups. Immunohistochemical staining resultd showed that

compared with B group

C group and D group increased the expression of PP-2A positive cells significantly

while the number of GSK-3 positive cells were significantly reduced. Conclusion: Xiaoyao San can improve the spatial memory ability of AD rats

the expression is related to its up-regulatiing expression of PP-2A and inhibitory prefrontal GSK-3β.