Objective: To observe the effects of salt-processing Eucommiae Cortex on BMD and serum hormone in rats after ovariectomy. Method: The model of postmenopausal osteoporosis was developed by ovariectomy

the rats were randomly divided into six groups

including sham operation group

model group

Nilestriol group

and salt-processing Eucommiae Cortex high

moderate

low-dose group(6

3

1.5 g·kg-1

ig)7 days later

successive administration was carried out

lasted for 12 weeks. The lumbar spine and femoral bone BMC and BMD

serum E2 and IGF-I content were assayed. Result: Compared with control group

BMC and BMD in model group rats decreased obviously

serum E2

IGF-I level decreased.Compared with model group

salt-processing Eucommiae Cortex could increase BMC and BMD

and serum E2

IGF-I level in rats after ovariectomy(P<0.05). Conclusion: Processing can enhance the anti-osteoporosis effect of Duzhong

salt-processing Eucommiae Cortex can prevent and delay osteoporosis in rats after ovariectomy by increasing serum E2

IGF-I level.