Objective: To investigate the anti-diabetic effect of Danzhi Jiangtang capsule (DJC) on experimental diabetic rats. Method: Experimental diabetic model in rats was induced by the injection of streptozocin. The models were divided randomly into 6 groups:model group (normal saline ig)

phenformin hydrochloride group (75 mg·kg-1

ig)

Tangmaikang group (1.5 g·kg-1

ig) and DJC low

middle

high dose (13

6.5

3.2 g·kg-1

ig) groups (n=8 each). Rats were selected as normal group (nomal saline ig). After 20 days of administration

effects of body weight

blood glucose

glucose tolerance and insulin level of rats were observed. Result: The DJC high dose group could significantly decrease level of fasting blood glucose (P<0.01) and improve glucose tolerance (P<0.01). All the DJC groups could significantly increase body weight of diabetic rats (P<0.01

P<0.05) and decrease level of glycosylated serum protein (P<0.01). No obvious effect of DJC on insulin level. Conclusion: DJC has significant anti-diabetic effect on experimental diabetic rats.