Objective: To observe the clinical efficacy of Danhong Huayu in treatment of diabetic retinopathy (DR) and the influence on vascular endothelial cell growth factor (VEGF) and basic fibroblast growth factor (bFGF). Method: sixty patients were randomly divided into observation group (n=30

58 eyes) and control group (n=30

57 eyes). Patients in control group were given Calcium Dobesilate Capsules(0.5 g/time

take orally

3 times/d

2 times/d after 6 weeks). Patients in observation group were given Danhong Huayu (20 mL/time

taken orally

3 times/d). Both groups were taken 12 weeks as one cycle. VEGF level

bFGF level and blood rheology indexes were tested. Result: The total efficacy of the observation group (82.75%) was significantly better than the control group (66.67%) (P<0.05). After treatment

visual acuity was improved and observation group was superior to control group (P<0.01). Eye fundus microvascular lesion severity score

QMG score for macular edema and retinal total cycle time were decreased obviously

observation group was superior to control group (P<0.01);VEGF and bFGF levels significantly decreased after treatment (P<0.01) and observation group were lower than control group (P<0.01). Improvements in blood rheological indexes such as whole blood viscosity

plasma viscosity

fibrinogen

erythrocyte deposited and erythrocyte sedimentation rate in observation group were better than control group (P<0.01). Conclusion: The shenshu Granule in treating of nonproliferative diabetic retinopathy have significant clinical effect and it can improve blood circulation

improve immune function

reduce VEGF

bFGF levels

slow DR progresses.