Objective: To observe the clinical efficacy of precocious prescription in the treatment of idiopathic central precocious puberty (ICPP) girls. Method: Eighty two female patients with ICPP were received the treatment of the precocious prescription. The traditional Chinese medicine syndromes

the change of gonads (breast size

uterine volume

ovarian volume

follicle diameter) and serum sex hormone (follicle stimulating hormone

luteinizing hormone

estradiol) were observed before and after treatment. Result: After treatment

the traditional Chinese medicine syndrome score

the breast Tanner score and the follicle diameter were obviously improved. The volumes of uterine and ovarian were reduced in varying degrees

and the serum sex hormone levels also had different degrees of decline. Conclusion: Precocious prescription can reduce the sex hormone levels of the ICPP girls

and also effectively control and delay the maturity and the speed of gonadal development. It's a safe and effective method to treat ICPP.