Objective: To observe the effect of Xiaoshuan capsule on hemorheology and vascular endothelial function in patients with cerebral ischemic stroke of qi deficiency and blood stasis type

to evaluate the possible mechanisms in patients with CIS. Method: Eighty patients with CIS of qi deficiency and blood stasis type were randomLy divided into two groups:the control group (40 cases) was given conventional treatment methods;Xiaoshuan group (40 cases) was given Xiaoshuan capsule 0.4 g once

three times daily. These patients of two groups were treated for 3 months. The scores of neurological deficit and activities of daily living were evaluated

and changes in blood rheology and endothelial function indicators were observed before and after treatment. Result: Before the treatment

indicator of national Institutes of health stroke scale(NIHSS) score

Barthel index

blood rheology

blood lipids and vascular endothelial function indicators were no significant difference between two groups. Before treatment

there were significant difference in these indicators between two groups and the health group(all P<0.01);after treatment

total efficiency in Xiaoshuan group was higher than that in control group(P<0.05);NIHSS score

Barthel Index

blood rheology and vascular endothelial function indicators in the Xiaoshuan patients were better than that in the control group(P<0.05 or P<0.01);Xiaoshuan capsule had no adverse reactions. Conclusion: It is safe and effective that Xiaoshuan capsule in the treatment of patients with cerebral ischemic stroke of qi deficiency and blood stasis type

the mechanism may be achieved through improving blood rheology

vascular endothelial function.