Objective: To prepare porous medical chitosan membranes and do their performance characterization. Method: Membranes were prepared by solvent evaporation gel method

degradation of chitosan enzyme to prepare porous chitosan membranes

then their morphology was observed by scanning electron microscope

weighing method was adopted to detect relationship between moisture absorption effect and hydrolysis time-remaining weight

and test adsorption of porous chitosan membranes to bovine serum albumin and controlled release properties to silver sulfadiazine. Result: Ratio of chitosan and endonuclease was 0.1 g·U-1

enzymolysis time was 3 h

both surface and internal of membranes generated porous structure which was suitable for pharmaceutical carriers. Conclusion: In situ endonuclease digestion of porous chitosan membranes had advantages of mild reaction conditions

pore rate controlled and non-toxic substance residues etc

which had a good application prospect.