Objective: Observed Qingyi Chengqi decoction oral and Shuangbai Sanjie powder external application treated severe acute pancreatitis (SAP) and effect of serum cytokines. Method: The 80 patients with SAP were randomly divided into control group and observation group. Each group had 40 patients. 2 groups were reference to the'Severe Acute Pancreatitis Treat Guide'. Fasting

gastrointestinal decompression

Supplemented the blood volume

corrected water electrolyte acid-base balance

somatostatin

omeprazole

antibiotics treated. Observation group in on the basis of the control group with Qingyi Chengqi decoction oral and Shuangbai Sanjie powder external application treated. The treatment lasted 7 d. Recorded abdominal pain

abdominal bloating remission

recovery of bowel sounds and ventilation defecation time

recorded the hemogram

blood

urine amylase recovery time and average hospitalization time and average hospitalization costs. Before and after treatment we tested serum interleukin-6 (IL-6)

interleukin-10 (IL-10)

interleukin-15 (IL-15) and tumor necrosis factor-alpha (TNF-α) levels. Result: The total effective rate of observation group was 97.5% better than the 80% of the control group (P<0.05);the observation group abdominal pain and abdominal bloating remission time

the recovery of bowel sounds time and the time of first defecation time were shorter than the control group (P<0.01);observation group

average hospitalization time and average hospitalization costs was less than that of the control group (P<0.01);the observation group normal hemogram time

blood

urine amylase recovery time were shorter than the control group (P<0.01);observation group serum IL-6

IL-15 and TNF-α level decreased significantly

and lower than the control group (P<0.01)

the observed serum IL-10 significantly increased and higher than control group (P<0.01). Conclusion: Qingyi Chengqi decoction oral and Shuangbai Sanjie powder external application could be significantly improved with SAP in acute abdominal pain

bloating and other symptoms of intestinal paralysis

adjusted the level of serum inflammatory factors

relieved pancreatitis systemic damage

which would facilitate the rehabilitation of the disease.