Objective: To prepare Panax notoginseng saponins liposome pellets. Method: With entrapment efficiency as index

orthogonal design was adopted to investigate effects of proportion of soybean phospholipid and cholesterol

ratio of water phase and organic phase

the concentration of drugs and lipid dosage on formulation technology of P notoginseng saponins liposome lyophilized powder

then P notoginseng saponins liposome pellets was prepared by plastic method. Result: Optional formulation technology of P notoginseng saponins liposome lyophilized powder were as follows:proportion of soybean phospholipid and cholesterol (6: 1)

ratio of water phase and organic phase (1: 4)

the concentration of drugs 20 g·L-1

lipid dosage 150 mg.After dissolved of prepared liposome pellets

average particle size of liposomes was 220.5 nm

Zeta potential was-71.2 mv

dissolution was up to 81.41% within 1 h. Conclusion: Dissolution of prepared P notoginseng saponins liposome pellets was high

particle size distribution of liposomes was well and quality was stable.