Objective: To study and compare the effective components of Semen Trichosanthis from different prodution regions. Method: The contents were detected by the HPLC

in 3

29-Dibenzoyl rarounitriol as reference

with methanol-water (93: 7) as the mobile phase

to 230 nm as the detection wavelength. Result: There are significant differences of content in 45 samples

Shandong Pingyin 025 samples containing up to 0.289 1%

Shandong Feicheng 001 was 0.078 1% minimum content of the sample. The change of 3

29-Dibenzoyl rarounitriol content was relatively large

and the stability is relatively low in each region and sub-interval.The highest content from the region of Changqing

Shandong

and the contents change were stability.The average content of Shandong Feicheng areas is up to 0.141 7%

but its stability is lowest. Conclusion: The results indicated that the average content of the six production regions all match the standard of the national

but the difference between regions were significant

and their stability lower.