Objective: To observe the effect of Shanmai capsules on the renal arteriole remodeling in renovascular hypertensive rats. Method: The two-kidney one-clip (2K1C) renovascular hypertensive rats were randomly divided into model group(n=8)

captopril group(0.007 g·kg-1

n=8)

Shanmai capsules high(1.8 g·kg-1

n=8)

middle(0.9 g·kg-1

n=7)

low(0.45 g·kg-1

n=6) dosage group and the sham control group(n=10). Treatment was started at the 5th week after surgery by intragastric administration. Systolic blood pressure (SBP) was measured periodically. Rats were sacrificed after the last administration. Angiotensin Ⅱ(Ang Ⅱ)and endothelin(ET)were measured by enzyme-linked immunosorbent assays(ELISA). The morphometric measurements were performed in the renal arteriole remodeling. Result: The blood pressure of rats after renal artery narrow operation was significantly higher than before(P<0.01). Compared with model group

the antihypertensive effect of Shanmai capsules on renal hypertensive rats was reversible with a concentration dependent manner. The AngⅡand ET level in plasma and the renal arterial media thickness(Mt) were decreased

and lumen diameter(RAD) and luminal cross-sectional area(Lcsa) were increased

differences were statistically significant(P<0.01

P<0.05). Conclusion: Shanmai capsules could inhibit the renal arteriole remodeling in renovascular hypertensive rats

and its mechanism may be related to the antihypertensive effect and reducing the levels of AngⅡand ET in vivo.