Objective: To investigate the effect of Zishui Qinggan Yin (ZSQGY) on estrogen level

cholesterol level and the endometrial thickness of ovariectomized rats after endocrine therapy. Method: Ovariectomized rats were treated with Letrozole(0.23 mg·kg-1)to mimic climacteric syndrome of breast cancer patient after endocrine therapy. Rats were randomly divided into five groups(n=7) and were orally administered corresponding drugs once per day for 6 weeks:sham group

model control group

positive control group(Remifemin 0.026 g·kg-1)

ZSQGY high and low dose group(45.10

11.28 g·kg-1). The body weight of rats was recorded each week. After the treatment

blood plasma was collected by abdominal aortic method

plasma estradiol(E2)

progesterone(PRO)

total cholesterol(CHO)

triglycerides(TG)

high density lipoprotein cholesterd(HDL-C)

low density lipoprotein cholesterd(LDL-C) were detected

pathological detection was processed by endometrium thickness. Result: After treatment

the average weight of ZSQGY high and low group were lower than that of model group(P<0.05). Compared with model group

the serum level of E2

PRO

CHO

TG

LDL-C of ESQGY were significantly decreased (P<0.05) which were still higher than sham group; the serum level of HDL-C of ESQGY high dose group was incseased(P<0.05).The ZSQGY groups and remifemin group have no obvious difference in endometrium thickness compared with the model group. Conclusion: ZSQGY can reduce the blood lipid without increasing the E2

PRO level and endometrium thickness.