Objective: To investigate effects of Dendrobii Officinalis Caulis on serum lipid and inflammation-related proteins in ApoE-/- mice

and explore its anti-atherosclerotic mechanisms. Method: ApoE-/- mice were fed a high-cholesterol diet for 4 weeks to induce atherosclerosis mode

then they were given simvastatin(3 mg·kg-1)

Dendrobii Officinalis Caulis (1.5

3 g·kg-1) by gavage

respectively.They were sacrificed after treated with drugs for 8 weeks continuously

and plasma lipid was determined by enzymatic method

expression of TNF-α and IL-6 was measured by ELISA

aortic plaques formation was stained with sudan IV

aortic lumen of atherosclerotic plaques were stained with oil red O and Hematoxylin-eosin

and expression of TNF-α and IL-6 in aortic arches was detected with immunohistochemical method. Result: Dendrobii Officinalis Caulis could reduce TG

TCHOL

LDL-C levels in serum significantly and reduce expression of TNF-α and IL-6;It also could inhibit or slow down formation of atheromatous plaque in aortic valve and aortic arch atherosclerotic plaque areas of ApoE-/- mice

then decreased expression of TNF-α and IL-6 in aortic arch. Conclusion: Dendrobii Officinalis Caulis could reduce serum lipid content

inhibit expression of TNF-α and IL-6 in serum and aortic of ApoE-/- mice

and then reduced inflammatory reactions and relieved atherosclerotic damage.