Objective: To explore the curative effect of Duhuo Jisheng decoction combined with sodium hyaluronate injection in articular cavity injection in the treatment of knee osteoarthritis. Method: One hundred and fifty cases of patients with knee osteoarthritis received in our hospital were randomly divided into three groups according with 50 cases in each group. Duhuo Jisheng decoction group was given alone Duhuo Jisheng decoction for the treatment

sodium hyaluronate group was given sodium hyaluronate injections alone

combined group was given injection of sodium hyaluronate and taken Duhuo Jisheng decoction. The efficacy

VAS pain scores

serum C-reactive protein levels and adverse reactions in the three groups of patients were compared. Result: The total effective rate in combination group was 94%

significantly higher than Duhuo Jisheng decoction group (80%) and sodium hyaluronate group (78%)

the differences were statistically significant (P <0.05); VAS scores in combination group after treatment was significantly lower than Duhuo Jisheng decoction group and sodium hyaluronate group

the differences were statistically significant (P <0.05); CRP levels in combination group after treatment were significantly decreased compared with Duhuo Jisheng decoction group and sodium hyaluronate group

the differences were statistically significant (P<0.05). Conclusion Duhuo Jisheng decoction combined intra-articular injection sodium hyaluronate for the treatment of knee osteoarthritis had good efficacy

could quickly relieve pain and improve function

worthy of clinical promotion.