Objective: To optimize formulation technology of matrine solid lipid nanoparticles and investigate its appearance and particle size distribution. Method: Matrine solid lipid nanoparticles were prepared ultrasonic dispersion method

with entrapment efficiency of matrine as index

orthogonal test was adopted to investigate effects of ratio of matrine-stearic acid

ratio of stearic acid-soybean lecithin

poloxamer concentration and oil-water phase ratio on formulation technology. Result: Optimum formulation technology was as following:matrine-stearic acid (1:6)

stearic acid-soybean lecithin (1:1)

poloxamer concentration 12 g·L-1

oil phase-water phase (1:5).Prepared matrine solid lipid nanoparticles was emulsion solution with luster

showed ivory white

it may produce white flocculus after shaking

average encapsulation efficiency was 82.8%

average drug loading was 5.5%.These nanoparticles were irregular spherical or ellipsoidal with uniform distribution

average particle size was 155 nm. Conclusion: Optimzed formulation technology was feasible and stable with good application prospects.