Objective: To investigate the changes of active composition in different parts and growth stages of Scutellaria baicalensis in Shandong Province. Method: HPLC technology was employed to detect the content of active composition in two-years old plant samples which collected from Laiwu and Pingyin in five different growth stages. Result: The content of scutellarin got to the highest value of 15.46

11.83 mg·g-1 in the part of aboveground in the beginning of flowering stage and leaf-expansion stage

respectively. The content of baicalin and wogonoside in the root which collected from Laiwu decreased in the whole growth stage

the content was 173.60

34.31 mg·g-1respectively

while the content in the samples collected from Pinyin was 176.40

212.94 mg·g-1in flower stage and 28.93

34.21 mg·g-1 in mature stage respectively. The content of baicalein in the sample of Laiwu was 8.05

9.49 mg·g-1in the beginning of flowering stage and maturity stage respectively. The content of wogonin was 1.94

3.75 mg·g-1 in the beginning of flowering stage and withering stage respectively

while the content was 12.80

8.27 mg·g-1and 2.70

1.48 mg·g-1 in leaf-expansion and withering stage in the samples collected from Pingyin. Conclusion: The content of scutellarin in aboveground is higher than that in underground which opposite to the content of baicalin; the content of baicalin and wogonoside from leaf-expansion to withering stage shows a trend of M style

while the content of baicalein and wogonin shows a trend of N style.