Objective: To study the effect of Xingnao Yizhi capsule with different proportions on learning and memory abilities in Alzheimer's disease rats and find the optimal proportion. Method: Male Wistar rats were randomly divided into 12 groups as following:sham operation group

model group

huperzine-A(0.05 mg·kg-1) group

Xingnao Yizhi capsule group and 8 effective parts with different proportions. After 3 days of routine breeding

Morris water maze was used to train the rats for 7 days. Alzheimer's disease model was reproduced by 1.25% D-galactose intraperitoneal injection(4 mL·kg-1)for six weeks

combined with β-amyloid protein 1-40 (Aβ1-40) hippocampal injection 2 μL(5 g·L-1). One week after modeling

drugs were administered to rats by intragastric administration once every day for a month

evaluating rat learning and memory function with different proportions by Morris water maze test. Result: Compared with the model group

all groups improved the space learning ability. The mean escape latency was significantly shortened in place navigation test and the frequency of passing through the platform was obviously increased in spatial probe test

which showed an obvious difference in Morris water maze

more obviously in Xingnao Yizhi capsule(borneol:icariin:total polygala tenuifolia saponins:total Radix notoginseng saponins 45:6.8:32.6:0). Conclusion: Xingnao Yizhi capsule effective parts with different proportions have the effect of improving space learning and memory function

while the effect intensity may be different.