Objective: To observe effect of Qiwei Wenyang softcapsule on pituitary-adrenal cortex system and pituitary-gonadal system function in animal kidney Yang deficiency model. Method: The high dose of hydrocortisone was used to establish the kidney Yang deficiency model

at the same time

Qiwei Wenyang soft capsule was given

and serum corticotrophin(ACTH) and cortisol level preputial gland

seminal vesicle organ index

the mice swimming time and hypoxia tolerance time were observed. Result: The high and medium dose Qiwei Wenyang softcapsule (0.96

0.48 g·kg-1) could obviously increase the serum ACTH and cortisol levels(P<0.05)in rats

1 and preputial gland organ index in mice (P<0.05)

Qiwei Wenyang softcapsule at dose of 0.68

0.34 g·kg-1 could obviously increase seminal vesicle organ index(P<0.05 or P<0.01); significantly prolong the swimming time and the normal pressure hypoxia tolerance time at dose of 1.35

0.68

0.34 g·kg-1 of mice(P<0.05). Conclusion: Qiwei Wenyang softcapsule has a protective effect on kidney Yang deficiency model.