Objective: To investigate anti-fatigue effect of Fufang Ejiao Jiang on mice. Mehtod: Sixty selected male mice were divided randomly into 5 groups:the control group

ginseng extract group(10 g·kg-1) and the low

medium

high dose Fufang Ejiao Jiang intervention groups(7.5

15

30 g·kg-1). Using the method of the weight loading swimming test

drugs were administrated to mice for 30 days.The contents of lactic acid(LA)

hepatic glycogen

haemoglobin(Hb)

malondialdehyde(MDA)

lactate dhydro-genase(LDH)

creatine kinase(CK)

blood urea nitrogen(BUN) and the activities of glutathione peroxidase(GSH-Px)

superoxide dismutase(SOD) in rats were dectected. Result: Compared with the control group

the low

medium and high dose groups after exercise

the content of LA

MDA was obviously reduced

the content of Hb was obviously increased(P<0.05); the medium

high dose groups had a higher content of hepatic glycogen

BUN

a lower content of CK and a higher activity of GSH-Px(P<0.05);the medium dose group had a lower content of LDH(P<0.01) and a higher activity of SOD(P<0.05). Conclusion: Fufang Ejiao Jiang can be effective in delaying fatigue and improve tissue on fatigue resistance.