Objective: To select Mussaenda extract on animal models of inflammatory

antibacterial research and analysis. Method: The mice were randomly divided into control group

positive control group and M.parviflora extract high

medium and low dose group (24

12

6 g·kg-1) administered orally

using xylene-induced mouse ear profile swelling

granuloma; carrageenan-induced rat paw edema inflammation model

and antibacterial experiments in vitro evaluation M. parviflora extract anti-inflammatory

effect. Result: M. parviflora extract significantly inhibited mouse ear edema(P<0.05)

as well as rat granuloma rat paw edema formation(P<0.05); M. parviflora extract on a variety of pathogenic bacteria were inhibited(P<0.05)

the minimum inhibitory concentration (MIC50) Staphylococcus aureus 0.95 μg·mL-1

E. coli 0.75 μg·mL-1

pneumococcal 0.65 μg·mL-1

Streptococcus 0.50 μg·mL-1

Shigella 0.25 μg·mL-1. Conclusion: M.parviflora extract on acute and chronic inflammation and in vitro inhibition significantly inhibitory effect.