Objective: To observe efficacy of Pingchuang paste in treatment of chronic obstructive pulmonary disease(COPD)

and explore its possible mechanism. Method: One hundred and sixty cases of COPD patients met the inclusion criteria were divided into the treatment group and the control group

80 cases in each group. The treatment group was treated with COPD conventional therapy (bronchodilator+expectorant+Seretide 50/250 1 suction bid+antibiotics)+and Pingchuang paste; the control group received COPD conventional therapy with no Pingchuang paste(bronchodilator+expectorant+Seretide 50/250 1 suction bid+antibiotics)

respectively

before and after treatment of 6 months the pulmonary function was measured

major indexes including FEV1 predicted

FEV1/FVC

6-minute walk test and quality of life scores (application SGRQ). Result: The treatment group compared with before treatment FEV1 was improved

the difference was statistically significant (P<0.05)

while in the treatment group and the control group the improvement of FEV1/FVC was not found. 6 min walk in the treatment group improved significantly compared to the control group

the difference was statistically significant (P<0.05).After treatment

the SGRQ scale declined than before treatment in two groups (P<0.05). Some symptoms

the active part of the score was declined significantly (P<0.05). Conclusion: Pingchuang paste can improve pulmonary function and clinical symptoms

and improve exercise tolerance

so as to achieve the purpose of improving the quality of life.