Objective: To discuss the clinical efficacy of Pingchong Huayu Tongluo method combined with moxibustion therapy on treating endometriosis dysmenorrhea and the influence on nerve growth tactor(NGF) and prostaglandin(PGs). Method: Sixty-three patients with endometriosis dysmenorrhea were randomly divided into observation group (n=32) and control group (n=31). Patients in the two groups were both treated with moxibustion therapy. Pingchong Huayu Tongluo method was used to treat the observation group. Three menstrual cycles as one cycle. Dysmenorrhea Visual Analogue Scale(VAS) score was observed and modified B & B multidimensional scaling was used to evaluate the clinical symptoms. Serum NGF

PGF2a

PGE2 and 6-keto-PGF1a levels were tested. Result: The integrated effect of observation group(100%) was better than the control group(80.6%)(P<0.05); on the 2-3 weeks after treatment and follow-up period of the menstrual cycle

the observation group dysmenorrhea VAS scores were lower than the control group (P<0.01); After treatment

B & B multidimensional scale scores of observation group was lower than the control group (P<0.01)

serum NGF

PGF2a

PGE2 levels of observation group was lower than the control group (P<0.01)

6-keto-PGF1a of the observation group was higher than the control group (P<0.01). Conclusion: Pingchong Huayu Tongluo method combined with moxibustion therapy on treating endometriosis dysmenorrhea has significant effect

its mechanism may be related to decreased NGF levels and adjust the level of PGs.