Objective: To optimize extraction technology of total polyphenols from Cinnamomi Cortex and observe its effect on streptozotocin (STZ)-induced diabetic mice. Method: With yield of total polyphenols as index

effects of the concentration of ethanol

solid-liquid ratio

extraction temperature and extraction time on extraction technology were investigated by orthogonal test.Diabetic mice model was established with fasting plasma glucose(FPG) as index

successful modeling mice were divided into five groups

such as the blank control group

model control group

positive control group(metformin hydrochloride)

low-dose of total polyphenols from Cinnamomi Cortex group

high-dose group

effect of total polyphenols from Cinnamomi Cortex on blood glucose of streptozotocin (STZ)-induced diabetic mice was investigated. Result: Optimum extraction process was as following:extracted 60 min with 10 times the amount of 30% ethanol at 80℃;Average yield of total polyphenols from Cinnamomi Cortex was 3.9%

the mass fraction of it was 39.1%.Before administration

FPG of each group were (6.33±1.27)

(18.06±3.12)

(18.71±3.51)

(18.06±3.27)

(18.41±3.54) mmol·L-1

respectively;While after gavage 3 w

FPH were (5.36±1.06)

(31.59±2.94)

(25.08±3.35)

(15.33±4.02)

(12.50±3.85) mmol·L-1

respectively. Conclusion: Optimized technology was scientific and reasonable

it could be used as basis for trial production of total polyphenols from Cinnamomi Cortex.Total polyphenols from Cinnamomi Cortex had significantly decrease fasting blood glucose levels in diabetic mice.