Objective: To optimize preparation technology of Rhododendri Daurici Folium total flavonoids solid dispersions. Method: With polyethylene glycol 6000(PEG6000)

polyvinyl pyrrolidone(PVPK30 K30) and poloxamer 188 (Pluronic F68) as carrier respectively

suitable carrier melting-solvent method and solvent method were used to prepare solid dispersions with different proportion(1:1

1:2

1:4

1:6) of total flavonoids from Rhododendri Daurici Folium-carrier.With total flavonoids from Rhododendri Daurici Folium as detection index

in vitro dissolution of the dispersions was analyzed by UV

and Td of each solid dispersions was calculated. Result: Optimum preparation process was as following:with 4 times the volume of PVPK30 as carrier

dissolved in 20 times the amount of ethanol

rotary evaporation to remove ethanol at 50℃

in vitro dissolution of total flavonoids from Rhododendri Daurici Folium in PVPK30 solid dispersions were up to 100%.With PEG6000 as carrier

Td of solid dispersions with different proportion(1:1

1:2

1:4

1:6) of total flavonoids from Rhododendri Daurici Folium-carrier were 6.329

5.225

0.096

4.755 min

respectively;Pluronic F68 as carrier

Td were 4.045

3.561

0.018

0.026 min

respectively;PVPK30 as carrier

Td were 5.000

5.000

0.005

0.056 min

respectively. Conclusion: Solvent method could successfully prepare Rhododendri Daurici Folium total flavonoids solid dispersions with good solubilization effect

but this method was not suitable for industrial production.