Objective: To compare effects of different extraction processes for Tongmai oral liquid on experimental myocardial ischemia in mice. Method: Intraperitoneal injection of isoproterenol in mice to establish model of myocardial ischemia.Effects of Tongmai extract A

Tongmai extract B

commercially available Tongmai oral liquid and compound Danshen tablets on plasmic ATP content and myocardial tissue in mice were compared. Result: The concentration of plasmic ATP in model group

Tongmai oral liquid group

Tongmai extract A group

Tongmai extract B group

compound Danshen tablets group and blank control group were (197.06±77.78)

(239.60±60.90)

(328.21±84.27)

(318.42±70.87)

(271.13±66.45)

(475.93±94.98) μg·L-1

respectively;Myocardial tissue damage index of these groups were (2.26±0.86)

(1.16±0.28)

(0.59±0.17)

(0.76±0.23)

(0.68±0.12)

0

respectively.Treatment effect of Tongmai extract A and Tongmai extract B were significantly better than Tongmai oral liquid and better than compound Danshen tablets without significantly influence

but Tongmai extract A was slightly better than Tongmai extract B. Conclusion: After changing of extraction processes

Tongmai extract A and Tongmai extract B could significantly improve myocardial ischemia in mice by increasing heart function

treatment effect was significantly better than commercially available Tongmai oral liquid

wherein Tongmai extraction A showed more significant role.