螺旋藻多糖对胃溃疡大鼠胃黏膜的修复作用及对EGF和EGFR表达的影响

隋璐; 刘坤; 沈薇; 郝伟

doi:10.11653/syfj2013200162

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螺旋藻多糖对胃溃疡大鼠胃黏膜的修复作用及对EGF和EGFR表达的影响

更新时间：2024-01-04

- 螺旋藻多糖对胃溃疡大鼠胃黏膜的修复作用及对EGF和EGFR表达的影响
- Effect of Polysaccharide from on Mucosal Repair by Regulating the Expression of EGF and EGFR in Experimental Rats with Gastric Ulcer
- 中国实验方剂学杂志 2013年19卷第20期页码：162-165
- 作者机构：
- 作者简介：
- 基金信息：
  
  辽宁省教育厅科学技术研究项目(L2010548);沈阳市科学技术项目(F-13-318-1-45)
- DOI：10.11653/syfj2013200162
  中图分类号：
- 纸质出版日期：2013
- 稿件说明：
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隋璐, 刘坤, 沈薇, 等. 螺旋藻多糖对胃溃疡大鼠胃黏膜的修复作用及对EGF和EGFR表达的影响[J]. 中国实验方剂学杂志, 2013,19(20):162-165.

SUI Lu, LIU Kun, SHEN Wei, et al. Effect of Polysaccharide from on Mucosal Repair by Regulating the Expression of EGF and EGFR in Experimental Rats with Gastric Ulcer[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(20): 162-165.
隋璐, 刘坤, 沈薇, 等. 螺旋藻多糖对胃溃疡大鼠胃黏膜的修复作用及对EGF和EGFR表达的影响[J]. 中国实验方剂学杂志, 2013,19(20):162-165. DOI： 10.11653/syfj2013200162.

SUI Lu, LIU Kun, SHEN Wei, et al. Effect of Polysaccharide from on Mucosal Repair by Regulating the Expression of EGF and EGFR in Experimental Rats with Gastric Ulcer[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(20): 162-165. DOI： 10.11653/syfj2013200162.

摘要

目的: 观察螺旋藻多糖(PSP) 对胃溃疡大鼠胃黏膜表皮生长因子(EGF)及表皮生长因子受体(EGFR)表达及溃疡愈合质量的影响

探讨其治疗胃溃疡的作用机制。方法: 采用乙酸烧灼法制备实验性胃溃疡大鼠模型

给予高、低两个剂量的PSP干预治疗15 d后取材

HE染色观察胃黏膜厚度、黏膜肌层缺损度变化;免疫组化观察胃溃疡大鼠胃黏膜EGF及EGFR表达情况。结果: PSP对胃溃疡黏膜有一定的修复作用

可使溃疡细胞破损减少

胃黏膜厚度、黏膜肌层缺损度与模型组比较均有显著性差异

免疫组化可见PSP使胃溃疡大鼠胃黏膜EGF及EGFR表达上调。结论: PSP治疗胃溃疡的作用机制可能与增加EGF及EGFR蛋白表达上调促进溃疡愈合有关。

Abstract

Objective: To investigate the effect of polysaccharide from Spriulnia platensis(PSP)on expression of epidermal growth factor(EGF) and EGF receptor(EGFR) in mucosa of experimental rats with gastric ulcer

and to study the possible mechanism for therapy of stomach ulcer. Method: The gastric ulcer in rats was induced by acetic acid burning and treated with low and high dose of PSP separately for 15 days

the gastric mucosal thickness and muscularis mucosa defect were observed by HE staining

and the expression of EGF and EGFR were detected by immunohistochemical staining. Result: The ulcer in treatment group healed well compared with model group and control group

high dose of PSP could promote the healing of gastric ulcer

reduce muscularis mucosa defect significantly (P<0.01)

increased the expression of EGF and EGFR observably. Conclusion: There is evident therapeutic effect of PSP on the experimental gastric ulcer in rats

and its mechanism might be related to the increasing EGF and EGFR protein expression.

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