Objective: To study Sinisan on intercellular adhesion molecule-1(ICAM-1) and vascular cell adhesionmolecule-1(VCAM-1) in experimental (UC) rats. Method: The animals were divided into 5 groups

including the normal group

model group

Sini powder group

Chaishaozhi group and Chaishao group. The antigen emulsion made by fresh rabbit colonic mucosa were injected into the rats' bilateral paws

groins and backs in 1st

10th

17th

24th day to induce model. The normal group and model group were given with 10 mL·kg-1 distilled water;and Sinisan group was treated with 1.75 g·kg-1 Sinisan solution;and Chaishaozhi group was treated with Chaishaozhi 1.31 g·kg-1 Chaishaozhi solution;and Chaishao group was treated with with 0.88 g·kg-1 Chaishao solution. On the 29th day

the rats were sacrificed and drawn. ICAM-1 and VCAM-1 levels were detected with ELISA. Result: ICAM-1 levels in blood of model group(64.60±4.81)μg·L-1 were higher than normal group(42.35±3.02)μg·L-1

P<0.05

and VCAM-1 levels(0.29±0.01)μg·L-1 higher than normal(0.20±0.02)μg·L-1

P<0.05.VCAM-1 levels in colon mucosal tissue of model group(1.82±0.19)μg·mg-1 higher than normal group(1.29±0.10)μg·mg-1

P<0.05.Sini san could significantly reduce ICAM-1(53.87±2.60)μg·L-1

VCAM-1(0.22±0.01)μg·L-1 levels in blood

and VCAM-1(1.41±0.08)μg·mg-1in colon mucosal tissue

P<0.05. Conclusion: The mechanism of intervening experimental UC by Sinisan is related to the balance of cytokine network.