Objective: To observe the effect of Miao medicine Tongqiao Huashuan decoction on brain tissue ultrastructure of bolt in rats with focal cerebral ischemia/reperfusion injurys. Method: SD rats were randomly divided into 5 groups (Tongqiao Huashuan decoction high dosage group

middle dose group

low dose group

model group

sham operation group).The middle cerebral artery occlusion (MCAO)was used to establish focal cerebral ischemia-reperfusion model. The corresponding Tongqiao Huashuan decoction (17.50

8.75

4.35 g·kg-1·d-1)

saline gavage were given for 15 days. The brain tissue superoxide dismutase (SOD) activity

malondialdehyde (MDA) content and ultrastructure of brain tissue were observed. Result: Compared with the sham operation group

MDA in model group was significantly increased

SOD activity was significantly decreased (P<0.05);compared with the model group

Tongqiao Huashuan decoction reduced the MDA content in brain tissues

increased the activity of SOD (P<0.01). Tongqiao Huashuan decoction could reduce the damage of brain tissue after cell apoptosis. Conclusion: High doses of Tongqiao Huashuan decoction could obviously alleviate the degeneration and necrosis of nerve cells and reduce apoptosis

its mechanism may be related to eliminate free radicals.