Objective: To evaluate the effect of Mongolian medicine ‘Lianqiao-4 Ingredient Soup Powder' on the acute liver injury of rats caused by pylorus ligation. Method: Model of acute liver injury was induced by using pylorus ligation. After making model of 16 h indexes of alanine aminotransferase(ALT)

aspartate aminotransferase(AST)

nitric oxide(NO)

nitric oxide composite enzyme(NOS)

cholinesterase(CHE)

urea nitrogen(URE)

total cholesterol(CHO)

triglyceride(TG)

low density lipoprotein(LDL-C)in serum

liver index and pepsin in the stomach homogenate in the normal group

model group

Mongolian medicine ‘Lianqiao-4 Ingredient Soup Powder' low

middle

high dose groups(1.3

2.6

3.9 g·kg-1)were determined respectively. Result: Compared with normal group

serum AST

ALT

BUN

NOS in the model group were increased significantly (all P<0.01);CHE

NO decreased significantly (P<0.05);MAO

CHO

TG

LDL-C level

liver index and activity of pepsin increased significantly (P<0.05). Compared with model group

AST

ALT

NOS

MAO

CHO

TG

LDL-C level

liver index and activity of pepsin in the high dose group of treatment were decreased significantly (P<0.05

P<0.01 respectively)

CHE and NO increased significantly (P<0.05). Low dose showed some influences for all indexes

but without significant difference compared with model group. Conclusion: Significant protective action of Mongolian medicine 'Lianqiao-4 Ingredient Soup Powder' on the acute liver injury was found. And taking various elements into the comprehensive consideration

the middle dose group was the best.