Objective: Observed the Yinchenhao decoction Jiawei treated drug-induced liver injury (DILI) clinical efficacy. Method: One hundred and thirty cases of DILI patients were randomly divided into observation group and control group grouping by digital method

each group had 65 cases. Both groups were oral inosine tablets of 0.4 g/time

3 times/d. The Glucurolactone tablets were oral of 0.2 g/time

3 times/d. The control group was treated with polyene phosphatidylcholine capsules

2 pills/time

3 times/d. Observation group used Yinchenhao decoction Jiawei. 1 dose/d. Lasted for 4 weeks. Every week was monitoring of liver function change. We observed clinical symptoms signs. Before and after treatment we tested serum levels of interleukin-10 (IL-10)

gamma-interferon (IFN-gamma) levels. Result: After treatment

the observation group

the cure rate was 95.23%

better than 63.07% of the control group (P<0.05);After treatment

jaundice

fatigue

anorexia

nausea vomiting

skin rash itching

stool

hypochondriac pain and abdominal distension nausea scores were lower than the control group (P<0.01);after treatment

alanine aminotransferase(ALT)

glutamic-oxaloacetic transaminase(AST)

bilirubin(TBIL) were lower than the control group (P<0.01);after treatment

serum IL-10 was higher than control group

IFN-gamma was lower than the control group (P<0.01). Conclusion: Yinchenhao decoction Jiawei could be reduced in patients with ALT

AST

TBIL level

reduced the clinical manifestations such as jaundice

fatigue

anorexia

improved the clinical cure rate

and its mechanism may be related with regulated immune function.