Objective: To establish a new technology of mechanical compression for Myristicae Semen into frostlike powder and compare with traditional compression process. Method: With oil yield and properties as indexes

single factor tests were adopted optimize mechanical compression process with compression times and temperature as factors.With the contents of fatty oil

volatile oil

total lignans and dehydrodiisoeugenol before and after pressing into frostlike powder

then investigate effect of mechanical compression and traditional compression into frost-like powder to chemical composition in Myristicae Semen.The content of dehydrodiisoeugenol was determined by HPLC

chromatographic conditions were as follows:Diamonsil C18 column(4.6 mm×250 mm

5 μm)

column temperature 30 ℃

mobile phase of methanol-water gradient elution

detection wavelength 274 nm

flow rate 1.0 mL·min-1

injection volume 20 μL. Result: Optimized mechanical compression process was:compression temperature 80-90 ℃ with 2 times

oil yield 30.8%.Compared with raw products

the contents of fatty oil

volatile oil

total lignans

dehydrodiisoeugenol were all reduced after mechanical compression into frost-like powder

but it was similar to traditional compression into frost-like powder. Conclusion: Mechanical compression process was convenient

quick and suitable for industrial production

it could replace traditional compression method.