栀子超微粉与细粉中栀子苷的体外溶出度比较

熊慧; 郭舟; 赵静文; 王金辉

doi:10.11653/syfj2013210053

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栀子超微粉与细粉中栀子苷的体外溶出度比较

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- 栀子超微粉与细粉中栀子苷的体外溶出度比较
- Comparison of Dissolution of Jasminoidin from Ultrafine Powder and Fine Powder of Gardeniae Fructus
- 中国实验方剂学杂志 2013年19卷第21期页码：53-55
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- DOI：10.11653/syfj2013210053
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- 纸质出版日期：2013
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熊慧, 郭舟, 赵静文, 等. 栀子超微粉与细粉中栀子苷的体外溶出度比较[J]. 中国实验方剂学杂志, 2013,19(21):53-55.

XIONG Hui, GUO Zhou, ZHAO Jing-wen, et al. Comparison of Dissolution of Jasminoidin from Ultrafine Powder and Fine Powder of Gardeniae Fructus[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(21): 53-55.
熊慧, 郭舟, 赵静文, 等. 栀子超微粉与细粉中栀子苷的体外溶出度比较[J]. 中国实验方剂学杂志, 2013,19(21):53-55. DOI： 10.11653/syfj2013210053.

XIONG Hui, GUO Zhou, ZHAO Jing-wen, et al. Comparison of Dissolution of Jasminoidin from Ultrafine Powder and Fine Powder of Gardeniae Fructus[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(21): 53-55. DOI： 10.11653/syfj2013210053.

摘要

目的: 比较栀子超微粉和细粉中栀子苷的体外溶出度。方法: 建立HPLC测定栀子超微粉和细粉中栀子苷在不同时间点的溶出量

计算累积溶出率

采用浆法进行体外溶出试验

色谱条件为Wondasil C18色谱柱(4.6 mm×250 mm

5 μm)

流动相乙腈-水(15:85)

流速1.0 mL·min-1

检测波长238 nm

柱温30 ℃

进样量10 μL。结果: 栀子超微粉和细粉45 min时累计溶出率分别为92.82%

83.36%

T0.8分别为9.92

26.35 min

超微粉中栀子苷的溶出度和溶出速率均优于细粉。结论: 栀子微粉化有利于有效成分的快速溶出。

Abstract

Objective: To compare in vitro dissolution of jasminoidin between ultrafine powder and fine powder of Gardeniae Fructus. Method: Paddle method was adopted in vitro dissolution test.HPLC was developed for determining dissolution of jasminoidin from ultrafine powder and fine powder of Gardeniae Fructus in different periods

then calculated accumulative dissolution

chromatographic conditions were:Wondasil C18 column(4.6 mm×250 mm

5 μm)

mobile phase of acetonitrile-water(15:85)

flow rate 1.0 mL·min-1

detection wavelength 238 nm

column temperature 30 ℃

injection volume 10 μL. Result: Accumulative dissolution of jasminoidin from ultrafine powder and fine powder of Gardeniae Fructus were 92.82%

83.36%

T0.8 were 9.92

26.35 min

respectively.Dissolution and dissolution rate of Gardeniae Fructus ultrafine powder were all higher than fine powder. Conclusion: Micronization of Gardeniae Fructus contributed to dissolution of effective components.

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