Objective: To observe the plasma concentration of orcinol glucoside of Curculiginis Rhizoma in blood on normal and deficiency cold state in rats

to explore that the correlation of Curculigini Rhizoma metabolize and and biological effects. Method: Male SD rats were randomly divided into two groups

namely the normal group and the deficiency cold group. The deficiency cold rats were given hydrocortisone sodium succinate injection(20 mg·kg-1·d-1) by intramuscular for 14 days. From the 15th day Curculigini Rhizoma(30 g·kg-1·d-1) water extracts was given ig to two groups rats for 7 days. After the last time

blood was collected for detecting plasma concentration of orcinol glucoside at multiple time points by HPLC

and calculate metabolic parameters. Result: The plasma concentration was increased in deficiency cold rats at 20 min

plasma concentration reached the maximum at 120 min

high level was maintained to 300 min;time to maximum plasma concentration(Tmax) and area under the curve(AUC) were increased significantly(P<0.05). Conclusion: The plasma concentration is high level in deficiency cold rats

that may provide the material basis for biological effect of Curculiginis Rhizoma.