Objective: To explore the effects and mechanism of Fuzi Lizhong decoction(FZLZ) on immune cell factors in rats with spleen Yang deficiency syndrome. Method: One hundred Wistar rats were randomly divided into model group

FZLZ low-dosage group

middle-dosage group

high-dosage group of FZLZ and control group. Each group included 20 rats. Low-dosage group

middle-dosage group and high-dosage group were ig given with FZLZ according to 5

10

20 g·kg-1based on model group

once a day for four weeks. Then thymus index

spleen index

the contents of interleukin(IL) -2

IL-6

IL-10 and tumor necrosis factor-α(TNF-α) were examined. Result: Compared with control group

thymus index

spleen index

the contents of IL-2

IL-6 and TNF-α in model group reduced (P<0.05 or P<0.01)

however

the content of IL-10 increased significantly (P<0.01). Compared with model group

thymus index

spleen index

the contents of IL-2

IL-6 and TNF-α in both middle-dosage group and high-dosage group increased (P<0.05 or P<0.01)while the content of IL-10 reduced (P<0.05 or P<0.01). Conclusion: Fuzi Lizhong decoction can improve immune function of rats with spleen Yang deficiency syndrome by regulating the contents of IL-2

IL-6

IL-10 and TNF-α

which may be one of the mechanisms.