Objective: To observe the influence of Liuwei Buqi capsule(LBC) on the expression of STAT4 and STAT6 protein and to study the therapeutic effects and possible mechanism in rat model with Fei-qi deficiency syndrome(FQDS) of chronic obstructive pulmonary disease(COPD). Method: The rats were randomly divided into normal group

model group

high dose of Liuwei Buqi group (0.16 g·kg-1)

low dose of Liuwei Buqi capsule group (0.04 g·kg-1)

Jinshuibao capsule group(49.5 mg·kg-1)

spleen aminopeptidase group(0.033 mg·kg-1)

(n=12). The rat model of lung deficiency of COPD was established by smoking rats and dripping the LPS into the trachea. At twenty-eight days after the modeling. corresponding drugs were given.The expression of STAT4 and STAT6 protein of lung tissue was observed. Result: Compared with the normal control group

the average optical density of STAT4 protein in lung tissue and the positive area in model group increased markedly

STAT6 protein decreased (P<0.01).Compared with the model group

the positive area of STAT4 became smaller and the average optical density became weaker

the positive area of STAT6 increased;meanwhile

no statistical significance was found among the treatment groups. Conclusion: The LBC can inhibit the expression of STAT4 protein

and promote the expression of STAT6 protein.