Objective: To investigate the effects of three different extracts from Malus toringoides (E Se)on experimental diabetic mice. Method: The mice were intraperitoneally injected with streptozocim(STZ

150 mg·kg-1) or alloxan(ALX)

200 mg·kg-1) to establish diabetic mice. Then the diabetic mice were administrated with E Se flavonoid(180 mg·kg-1)

E Se Jingao(900 mg·kg-1)and Kangzhu Ganlu(360 mg·kg-1) by intragastric in grouped mice respectively once daily for 4 days. All mice were fasted for 5 h before administration and the fasting blood glucose (FBG) was tested 1h after treatment. Body weight was determined by every other day. At the end of treatment

the mice were sacrificed in fasting condition after the FBG detection. The blood was collected for insulin and c-peptide detection. Once blood had been collected

the thymus and liver were immediately removed

individually weighed and expressed in relative terms. Result: Compared with the control group

the general behavior of mice treated with extracts from E Se became better and the FBG levels were significantly reduced(P<0.05). Significant increase in serum insulin (P<0.05) and decrease in c-peptide were detected in treated mice(P<0.05). The group of E Se Jingao and Kangzhu Ganlu showed a significant decrease in liver

relative masses compared with model group(P<0.05). Conclusion: The three different extracts from E Se all have a high hypoglycemic activity

further investigations are needed to explore the exact mechanism of action for antidiabetic effect.