Objective: To study the influence of Qisang Jiangtang Fang (Q-S) on blood glucose

serum lipoprotein in type 2 diabetes(T2DM) rats. Method: T2DM model was induced with high sucrose-fat diet for 4 weeks and streptozocin (STZ)ip for 40 mg·kg-1

rats were randomly divided into groups:model group

Q-S low dose(ig 180 mg·kg-1·d-1)and middle dose(ig 360 mg·kg-1·d-1)and high dose group(ig 540 mg·kg-1·d-1)

rosiglitazone treatment group(ig 4 mg·kg-1·d-1).Blood glucose

serum lipoprotein

hemoglobin Alc (HbAlc)

insulin (Ins)contents in rats were detected after 60 d of continuous medication. Result: Compared with normal group

HbAlc levels were significantly increased (P<0.01)

total cholesterol (TCH)

total triglyceride (TG)

low density lipoprotein (LDL) were significantly increased (P<0.05)

high density lipoprotein (HDL)decreased significantly (P<0.05) in model group. Q-S can reduce the levels of blood glucose

HbAlc

TG

TCH and LDL

improve the level of HDL and Ins

those were significant deviation compare dwith the model group(P<0.05)

it was no significant difference with the rosiglitazone treatment group. Conclusion: Q-S can effectively reduce rat's blood glucose of T2DM

promote Ins secretion

improve t the disorder of lipid metabolism in diabetic rats

regulate serum lipoprotein.