Objective: The purpose is to observe the curative effect of Tongfu Qingyi recipe in in adjuvant therapy of severe acute pancreatitis (SAP)and its protection function to intestinal barrier function. Method: Sixty-four cases of SAP patients were randomly divided into control group (32 cases) and observation group (32 cases) according to the digital method. Patients in both groups were given conventional western medicine treatment. On the basis of the control group

patients in observation group took Tongfu Qingyi recipe

stomach filling

1 dose/day

treatment course 10 days.Levels of serum D-lactic acid

diamine oxidase (DAO) and levels of plasma endotoxin and urinary lactulose/mannitol (L/M) values were monitored. The first defecation time

the abdominal pain relief time

the abdominal distension relief time and borborygmus recovery time were recorded. Levels of serum interleukin 6 (IL-6)

interleukin 8 (IL-8) and tumor necrosis factor-α(TNF-α)were detected before and after treatment. Levels of plasma thromboxane B2 (TXB2) and 6-ketone-prostaglandin F1a (6-keto-PGF1a) were detected before and after treatment. Occurrence rate

transit operation rate and mortality rate of acute respiratory distress syndrome (ARDS) and multiple organ dysfunction syndrome (MODS) were recorded within 4 weeks. Result: On the fifth and tenth day after the treatment

levels of serum D-lactic acid

DAO and endotoxin and urinary L/M value were significantly decreased and were lower than the control group (P<0.01). The plasma endotoxin level in both groups showed a increased trend and observation group was lower than control group (P<0.01). The first defecation time

the abdominal pain and distension relief relief time and borborygmus recovery time of observer group were all shorter than control group (P<0.01). After the treatment

levels of serum interleukin 6 (IL-6)

interleukin 8 (IL-8) and tumor necrosis factor-α(TNF-α) of observer group were lower than the control group (P<0.01) TXB2 level of observer group was lower than the control group

while 6-keto - PGF1a level was higher than the control group (P<0.01). Within the 4 weeks

the incidences of ARDS and MODS were 12.5% and 9.38%

which were lower than 37.5% and 31.25% of the control group (P<0.05). Conclusion: In the adjuvant therapy of SAP patients

Tongfu Qingyi recipe can alleviate intestinal paralysis and inflammatory injury

promote gastrointestinal function recovery and blood circulation. It protects the Intestinal barrier function of SAP patients and reduces the intestinal bacterial and endotoxin translocation

which further reduces the incidence of ARDS and MODS.