Objective: To discuss the clinical efficacy and mechanism of action of Yiqi Jiedu Ruangan decoction on patients with post-hepatitis B cirrhosis(PHBC)(compensated stage). Method: Seventy-six patients were randomly divided into observation group(n=38) and control group (n=38). Both groups were adopted conventional therapy such as liver protection

antiviral therapy. Control group was given Fuzheng Huayu capsule

1.5 g each time

3 times each day. Observation group were given Yiqi Jiedu Ruangan decoction

1dose each day

conventional decocting with water for 2 times

all for 24 weeks. Liver function such as alanine aminotransferase(ALT)

aspartate aminotransferase(AST)

total bilirubin(TBIL)

albumin(ALB)

the ratio of albumin and globulin(A/G) in pretherapy and post-treatment were tested

and indicators of hepatic fibrosis such as serum hyaluronic acid(HA)

laminin(LN)

serum procollagen type III(PCIII)

serum collagen type IV(IV-C) were detected. The thickness of the spleen and the diameters of the portal vein (DPV)

the diameters diameter of splenic vein(DSV)

the portal vein velocity (VPV)

the splenic venous blood flow (VSV) were determined by color Doppler ultrasound. The level of serum tissue inhibitor of metalloproteinase 1(TIMP-1)

transforming growth factor-β1(TGF-β1)

platelet-derived growth factor (PDGF) in pretherapy and post-treatment were tested

and indicators of hepatic fibrosis such as HA

LN

PCIII

IV-C were detected. The thickness of the spleen and DPV

DSV

VPV

VSV were determined by color Doppler ultrasound. the level of TIMP-1

TGF-β1

PDGF in pretherapy and post-treatment were tested. Result: The total effective rate of observation group(81.57%) were superior to control group(60.52%)(P<0.01);the level of ALT

AST

TBIL of observation group were descended than before and lower than control group(P<0.01);the level of ALB

A/G of both groups were risen and observation group were higher than control group(P<0.01 or P<0.05);the level of HA

LN

PCIII

IV-C of observation group were lower than control group(P<0.01);the improvement of the thickness of the spleen and DPV

DSV

VPV

VSV of observation group were superior to control group(P<0.01 or P<0.05);the level of TIMP-1

TGF-β1

PDGF of observation group were dramatic declined and lower than control group(P<0.01). Conclusion: Yiqi Jiedu Ruangan decoction can reduce the enzyme

protect liver function

anti-fibrosis and resist cirrhosis

and the mechanism of action may be related with reducing the level of TIMP-1

TGF-β1

PDGF. It is worthy of clinical use.