Objective: The purpose is to study the curative effect of Tiaochong Pinggan square on hypertension of patients in perimenopausal period and its influence on vascular endothelial function and neuroendocrine function. Method: Ninety cases of hypertension patients in perimenopausal period were randomly divided into control group (45 cases) and observation group (45 cases) according to digital method. The patients in both groups took psychological supportive treatment. Patients in control group took the oryzanol tablets (20 mg/time

3 times/day) and felodipine zyban tablets (5 mg/time

1 time/day). Patients in observation group took Tiaochong Pinggan square

1 dose/day

2 times/day

conventional water frying. Treatment course was 8 weeks. Kupperman index (KI) was used to record symptoms of perimenopausal syndrome

detecting blood pressure levels of patients. Levels of serum estradiol (E2)

follicle-stimulating hormone (FSH)

luteinizing hormone (LH)

nitric oxide (NO)

endothelin 1 (ET-1)

neuropeptide Y (NPY)

neural antihypertensive peptides (NT) and β-endorphin (β-EP) were measured. Result: After treatment

in fourth week

levels of SBP and DBP in both groups reduced

compared to the state before treatment (P<0.01). In eighth week

levels of SBP and DBP in both groups fall further

observation group was lower than control group (P<0.01). The rate of blood pressure recover was 68.89%

superior to 46.67% in the control group (P<0.05). The effect of blood pressure efficacy of observation group was 93.33%

better than 73.33% of control group (P<0.05). In 4 weeks after treatment and the end of the treatment

KI score of the observation group was lower than the control group (P<0.01)

while the descend range of KI score in observation group was superior to the control group (P<0.01). After treatment

E2 level of observation group was higher than the control (P<0.05)

but levels of FSH and LH were lower than the control group (P<0.01). ET-1 level of observation group declined and was lower than the control group (P<0.01). However

NO level of observation group increased and was higher than the control group (P<0.01). NPY of observation group was lower than the control group after treatment

while levels of NT and β-EP were higher than the control group (P<0.05). Conclusion: On the basis of psychological guidance treatment

Tiaochong Pinggan square can improve clinical symptoms of patients with perimenopausal syndrome

decreasing blood pressure level of patients and promoting the patients' blood pressure return to normal state. Its mechanism may be related to its regulation of vascular endothelial function and neuroendocrine function

which is worth of clinical use.