Objective: The purpose is to observe the clinical curative effect of this method in prevent recurrence of peptic ulcer (PU). Method: Ninety-six cases of PU patients were randomly divided into observation group (48 cases) and control group (48 cases). The patients in the control group took omeprazole enteric capsules by oral

20 mg/time

2 times/day. If the HP of patients is positive

they took conventional trigeminy anti HP treatment. The patients in the observation group took

1 dose/day. After the treatment

the patients in control group took omeprazole enteric capsules

20 mg/time

1 time/day

treatment course 4 weeks. While the observation group taking the Yuyang Xiaotong prescription during the 4 weeks. Gastroscope inspection was operated before and after the treatment to evaluate endoscopic mucosal maturity and histological regenerative mucosal maturity. By using immunohistochemical method to detect the express of ulcer mucous membrane spasmolysis peptide (SP) to observe the changes of clinical symptoms

taking 1 year follow-up visiting to observe the recurrence situations. Result: The total effective rate of gastroscope inspection of the observation group was 97.9%

higher than 85.4% of control group (P<0.05). The evolutions of endoscopic mucosal maturity and histological regenerative mucosal maturity in the observation group were superior to control group (P<0.01). The total effective rate of syndromes curative effect in the observation group was superior to that in the control group

with the rate 100% and 79.1% (P<0.01). After the treatment

the symptom score of stomach pain

bloating

eating less and stay

loose stool

belching

pantothenic acid and other symptoms was lower than the control group (P<0.01). The SP positive expression in the observation group was obviously increased (P<0.01). The recurrence rate of observation group was 26.8%

lower than 60.0% of the control group (P<0.01). Conclusion: This method can significantly reduce the clinical symptoms and increase the healing quality of PU

decreasing the recurrence rate. The curative effect in short term and long term was obvious. The action mechanism may be related to the increase of SP expression.