Objective: To evaluate the effects and safety of Zhengqing Fengtongning for ankylosing spondylitis.Method: Such database as PUBMED

EMBASE-ASP

Cochrane Library

OVID

Springer-link CNKI

VIP

Wanfang and CBM

ect

were searched from the date of their establishment to January 2013.The quality of included studies was evaluated

and meta-analysis was conducted with RevMan 5.1 software. Result: A total of 12 RCTs involving 1 112 patients were included. Meta-analysis showed that there were significant differences between the Zhengqing Fengtongning and western medicines groups in the effect on improving the total effective[MD=3.07

95%CI(1.88

5.02)]

total body pain[MD=-0.43

95%CI(-0.61

-0.24)]

spinal pain[MD=-0.31

95%CI(-0.44

-0.19)].Zhengqing Fengtongning injection would improved the total effective[OR=4.10

95%CI(1.73

9.71)]

VAS score[MD=-2.84

95%CI(-3.68

-2.00)].Zhengqing Fengtongning injection caused a higher incidence of allergic skin. Conclusion: Use high quality clinical trials to further prove the clinical effects and safety of Zhengqing Fengtongning for ankylosing spondylitis(AS) is necessary promptly.