冬瓜皮炭的炮制工艺优选及体外吸附尿毒素活性考察

王一硕; 张娟; 张振凌

doi:10.11653/syfj2013220009

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冬瓜皮炭的炮制工艺优选及体外吸附尿毒素活性考察

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- 冬瓜皮炭的炮制工艺优选及体外吸附尿毒素活性考察
- Optimization of Processing Technology and Investigation of Adsorption Activity for Urotoxin of Carbonized Benincasae Exocarpium by Baking
- 中国实验方剂学杂志 2013年19卷第22期页码：9-11
- 作者机构：
- 作者简介：
- 基金信息：
  
  河南省教育厅自然科学研究计划项目(2010A360031)
- DOI：10.11653/syfj2013220009
  中图分类号：
- 纸质出版日期：2013
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王一硕, 张娟, 张振凌. 冬瓜皮炭的炮制工艺优选及体外吸附尿毒素活性考察[J]. 中国实验方剂学杂志, 2013,19(22):9-11.

WANG Yi-shuo, ZHANG Juan, ZHANG Zhen-ling. Optimization of Processing Technology and Investigation of Adsorption Activity for Urotoxin of Carbonized Benincasae Exocarpium by Baking[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(22): 9-11.
王一硕, 张娟, 张振凌. 冬瓜皮炭的炮制工艺优选及体外吸附尿毒素活性考察[J]. 中国实验方剂学杂志, 2013,19(22):9-11. DOI： 10.11653/syfj2013220009.

WANG Yi-shuo, ZHANG Juan, ZHANG Zhen-ling. Optimization of Processing Technology and Investigation of Adsorption Activity for Urotoxin of Carbonized Benincasae Exocarpium by Baking[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(22): 9-11. DOI： 10.11653/syfj2013220009.

摘要

目的: 优选烘法制备冬瓜皮炭的炮制工艺并考察其体外吸附尿毒素活性。方法: 以冬瓜皮炭对尿素的吸附力和尿素收率为综合评价指标

采用正交试验考察制炭温度与制炭时间对冬瓜皮炭炮制工艺的影响。结果: 冬瓜皮炭的最佳炮制工艺为制炭温度280 ℃

制炭时间15 min

平均吸附力20.85 mg·g-1

RSD 2.83%。结论: 冬瓜皮炭体外具有吸附尿素氮、肌酐、尿酸等尿毒素的活性

可用于药品、保健品的制备

提高了冬瓜皮的药用价值

为新型、价廉、安全的治疗肾衰中药制剂的开发提供了新来源。

Abstract

Objective: To optimize processing technology of carbonized Benincasae Exocarpium by baking and investigate its in vitro adsorption activity of urotoxin. Method: With adsorption force of carbonized Benincasae Exocarpium on urea and urea yield as indicators

orthogonal test was adopted to investigate effects of processing temperature and time on processing technology of carbonized Benincasae Exocarpium by baking. Result: Optimum processing technology was as following:processing time 15 min

processing temperature 280 ℃;Under these conditions

average adsorption force of carbonized Benincasae Exocarpium on urea was 20.85 mg·g-1 with RSD of 2.83%. Conclusion: Carbonized Benincasae Exocarpium by baking had in vitro adsorption activities for urea nitrogen

creatinine and uric acid.It could be used for preparation of medicines and health products

and increase medicinal value of Benincasae Exocarpium as a new source in development of Chinese medicine preparations for treatment of renal failure with advantages of inexpensive and safe.

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